Preparation and evaluation of metformin hydrochloride loaded Niosomes for enhancement of oral Bio-availability
AUTHORS : Manoj Kumar Das, Mrinmoy Deka, Abdul Baquee Ahmed DOI No. : NA DOI Link. : NA The purpose of this study was to develop metformin hydrochloride loaded niosomes as controlled release drug delivery system for the treatment of diabetes mellitus. The aim of the present work was to develop metformin hydrochloride loaded niosomes by centrifuge technique using various type of surfactants and cholesterol. Surfactants used were (Span 40, Tween 80) and cholesterol was added. The prepared neosomes were evaluated by determination of particle size using photon correlation spectroscopy (Zetasizer Nano ZS, Malvern), determination of entrapment efficiency (E.E %) and in-vitro drug release study usingdialysis bag technique at phosphate buffer 6.8. The particle size of prepared niosome range between found to be 974.1 nm indicating that these vesicles were all of a small size. The poly-dispersity index(PDI) of the investigated vesicles showed values in the range of 0.141.The data obtained from the 8 hours release study of F2 formulation was found to be 84.60% and was considered to be the best formulation as it shows better linearity as compared to F1 and F3 formulations. The present study suggested that niosome formulations provide sustain and prolong delivery of drug with enhance Bio-availability.