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A descriptive review on the pharmacological screening methods on antidepressant activity of different plants extracts and comparison with tea extracts (Camellia sinensis)

AUTHORS : Diganta Deka, Jashabir Chakraborty, Biswajit Das, Debopratim Dasgupta, Sayantan Maitra, Purabi Das, Mustafizur M Rahman
DOI No. : NA
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Depression is the most common mental disorder occurring due to neurotransmitter imbalance. Antidepressant are the drugs which are use to treat neurotransmitter imbalance in depression. Antidepressant works by altering the bioamines level like norepinephrine, serotonine and dopamine neurotransmitters, which are directly related with general well being and cognitive function of brain. Various herbal remedies and dietary supplements are use to cure depression due to their CNS stimulating property. They may modulate neurotransmission through direct impact on receptors and they may also influence neurotransmitter synthesis or distribution such as GABA modulation, dopaminergic modulation. Tea (Camellia sinensis) contains many CNS active chemical constituents such as polyphenols, caffeine, theanine etc. among them the unique amino acids such as L-theanine, which having significant antidepressant activity in associated with very little side effect in comparison with conventional formulations. In this review work, focus was given to find the reported antidepressant activity of Tea. Then a comparison was established to find the antidepressant activity among tea and other plant on the basis of reported data. Experimental findings of common pharmacological screening methods for antidepressant activity in animal such as forced swimming test, tail suspension test and open field test etc. with its immobility and locomotion data were considered as the basis to compare the antidepressant activity. In these review it was found that Tea having a bit of better antidepressant which can be explore to substitute the known antidepressant in future.

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