In-vitro antidiabetic and antioxidant activity of Musa paradisiaca stamen.
AUTHORS : Ashish Mishra, Anupam Srivastava, Amita Sharma, Santosh Kumar Maurya DOI No. : NA DOI Link. : NA Objective: Musa paradisiaca belonging to family Musaceae is a well known herb having many pharmacological properties including anti-diabetic activity. In ancient text Basawaraja, the stamen of this plant was reported as antidiabetic agent in a dietary recipe. The main aim of present study was to explore the in-vitro antidiabetic property of stamen as well as antioxidant potential.
Methods: The aqueous extract of stamen of Musa paradisiaca (AqMP) was prepared. The in-vitro antidiabetic activity was determined by α-glucosidase and α-amylase inhibition assay. The in-vitro antioxidant potential of AqMP was determined via DPPH free radical scavenging, scavenging of hydroxyl radical and nitric oxide scavenging activity.
Results: The findings shows AqMP possess α-glucosidase and α-amylase inhibitory activity respectively. The IC50 value of AqMP was found to be 86.77 μg/mL and 55.09 μg/mL respectively and it was compare with standard drug acarbose (IC50= 55.09 and 45.06). The free radicals were scavenging potency increases as the concentration increases. The IC50 values were found to be 62.76 μg/mL, 72.54 μg/mL and 197.17 μg/mL respectively.
Conclusion: The study shows that the drug exhibit significant in-vitro antidiabetic and antioxidant activity.